The role of cortisol in the body.

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Cortisol is a hormone, which is mainly released at times of stress and has many important functions in your body. Having the right cortisol balance is essential for human health and you can have problems if your adrenal gland releases too much or too little cortisol.

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What is cortisol?

Cortisol is a steroid hormone that is produced by the adrenal glands which sit on top of each kidney. When released into the bloodstream, cortisol can act on many different parts of the body and can help:

• your body respond to stress or danger

• increase your body’s metabolism of glucose

• control your blood pressure

• reduce inflammation.

Cortisol is also needed for the fight or flight response which is a healthy, natural response to perceived threats. The amount of cortisol produced is highly regulated by your body to ensure the balance is correct.

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What triggers the adrenal glands to produce cortisol?

Cortisol production by the adrenal glands is regulated by the pituitary glands. The pituitary is a pea-sized gland at the base of the brain that is sometimes referred to as the "master gland" because of its wider effects on the body.

When you wake up, exercise or you’re facing a stressful event, your pituitary gland reacts. It sends a signal to the adrenal glands to produce just the right quantity of cortisol.

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What happens when you produce too much or little cortisol?

Your body usually produces the right amount of cortisol. In a condition such as Cushing’s syndrome, it produces too much. In a condition such as Addison’s disease, it produces too little.

Symptoms of too much cortisol include:

• weight gain, particularly around the abdomen and face

• thin and fragile skin that is slow to heal

• acne

• for women, facial hair and irregular menstrual periods.

Symptoms of not enough cortisol include:

• continual tiredness

• nausea and vomiting

• weight loss

• muscle weakness

• pain in the abdomen.

If you experience any of these symptoms, your doctor may suggest you have a blood test to measure your cortisol levels.

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What are corticosteroids?

If your body does not produce enough cortisol, your doctor may prescribe corticosteroids for you. Corticosteroids are synthetic versions of cortisol that can be used to treat a variety of conditions including:

• inflammatory conditions (such as asthma)

• Addison’s disease

• skin conditions (such as psoriasis).

Some people take them to build muscles, without a doctor’s prescription. This is risky.

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Are there any side effects of corticosteroid therapy?

Because corticosteroids are powerful medications, side effects are quite common. These may include:

• thinning skin

• osteoporosis

• weight gain, especially around the face

• diabetes

• rapid mood changes

• high blood pressure.

If you experience these side effects, it is important to talk to your doctor before stopping your medication.

Sources:

Australian Addison’s Disease Association (What is Addison’s?), Healthline (Cortisol level test), The National Institute of Diabetes and Digestive and Kidney Diseases (Adrenal insufficiency and Addison’s disease), Mayo Clinic (Cushing syndrome), MedlinePlus (Cortisol blood test), Mayo Clinic (Corticosteroid (oral route, parenteral route)), NHS Choices (Corticosteroids – side effects),MyVMC (Cushing’s syndrome)

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 All content displayed here is provided for general information purposes only, and should not be treated as a substitute for advice given by your GP or any other healthcare professional.